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KMID : 0380220070400020290
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Journal of Biochemistry and Molecular Biology
2007 Volume.40 No. 2 p.290 ~ p.294
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Saxatilin, a Snake Venom Disintegrin, Suppresses TNF-alpha-induced Ovarian Cancer Cell Invasion
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Kim Dong-Seok
Jang Yoon-Jung
Jeon Ok-Hee
Kim Doo-Sik
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Abstract
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Saxatilin is a disintegrin known to inhibit tumor progression in vivo and in vitro. The role of saxatilin in cancer cell invasion was examined by a modified Boyden chamber assay in MDAH 2774 human ovarian cancer cell line. Saxatilin (50 nM) significantly inhibited cancer cell invasion induced by tumor necrosis factor-alpha (TNF-alpha). Saxatilin also reduced MMP-9 mRNA levels in cancer cells in a dosedependent manner. In addition, TNF-alpha-induced MMP-9 activity was reduced by the treatment of saxatilin. These results indicate that transcriptional regulation of MMP-9 is an important mechanism for the tumor suppressive effects of saxatilin in MDAH 2774 human ovarian cancer cells.
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KEYWORD
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Disintegrin, Invasion, MMP-9, Ovarian cancer, TNF-&agr
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